Sphingolipid metabolism in cancer signalling and therapy
B Ogretmen - Nature Reviews Cancer, 2018 - nature.com
Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
P Chongsathidkiet, C Jackson, S Koyama, F Loebel… - Nature medicine, 2018 - nature.com
T cell dysfunction contributes to tumor immune escape in patients with cancer and is
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …
CD69: from activation marker to metabolic gatekeeper
D Cibrián, F Sánchez‐Madrid - European journal of …, 2017 - Wiley Online Library
CD69 is a membrane‐bound, type II C‐lectin receptor. It is a classical early marker of
lymphocyte activation due to its rapid appearance on the surface of the plasma membrane …
lymphocyte activation due to its rapid appearance on the surface of the plasma membrane …
The role of TH17 cells in multiple sclerosis: Therapeutic implications
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease
Immune cell trafficking is a critical element of the intestinal immune response, both in
homeostasis and in pathological conditions associated with inflammatory bowel disease …
homeostasis and in pathological conditions associated with inflammatory bowel disease …
Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway
Background and Purpose—White matter (WM) ischemic injury, a major neuropathological
feature of cerebral small vessel diseases, is an important cause of vascular cognitive …
feature of cerebral small vessel diseases, is an important cause of vascular cognitive …
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …
lipid mediator that regulates many processes in vertebrate development, physiology, and …
Inflammation, vitamin B6 and related pathways
PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
An update on the biology of sphingosine 1-phosphate receptors
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …