Population aging is one of the largest challenges of the 21st century. As more people live to
advanced ages, the prevalence of age-related diseases and disabilities will increase …

Since the discovery of single gene mutations that double its lifespan, the nematode
Caenorhabditis elegans has provided remarkable insights into the biology of aging. The …

Diet is a crucial determinant of organismal biology; interactions between the host, its diet,
and its microbiota are critical to determining the health of an organism. A variety of genetic …

Cooperation and cheating are widespread evolutionary strategies. While cheating confers
an advantage to individual entities within a group, competition between groups favors …

The nematode Caenorhabditis elegans is used extensively in molecular, toxicological and
genetics research. However, standardized methods for counting nematodes in liquid culture …

BAM15 was recently screened as a protonophore uncoupler specifically for the
mitochondrial membrane but not the plasma membrane. It is equally as potent as FCCP, but …

The nematode Caenorhabditis elegans is a powerful model organism for studying cell
development, apoptosis, neuronal circuits, and aging. The isolate N2 is recognized by the C …

The present study evaluated the toxicity of metal contamination in soils from an art glass
factory in Småland Sweden using a Caenorhabditis elegans nematode model. The aim of …

Aims Alzheimer's disease (AD), the most common neurodegenerative disorder associated
with aging, is characterized by amyloid-β (Aβ) plaques in the hippocampus. Ergosterol, a …

In many organisms, dietary restriction (DR) leads to lifespan extension through the activation
of cell protection and pro-longevity gene expression programs. In the nematode C. elegans …