Mitochondria, the membrane-bound cell organelles that supply most of the energy needed
for cell function, are highly regulated, dynamic organelles bearing the ability to alter both …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Most, if not all mitochondrial functions, including adenosine-5′-triphosphate (ATP)
production and regulation of apoptosis and Ca 2+ homeostasis, are inextricably linked to …

Mitochondrial morphology changes dynamically by coordinated fusion and fission and
cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are …

The meaning of the word mitochondrion (from the Greek mitos, meaning thread, and
chondros, grain) illustrates that the heterogeneity of mitochondrial morphology has been …

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting
network. The molecular machinery that mediates this organelle fission and fusion is …

Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …

Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into
ancient archaea species. During evolution, mitochondria lost most of the prokaryotic …

The complex and elaborate architecture of a neuron poses a great challenge to the cellular
machinery which localizes proteins and organelles, such as mitochondria, to necessary …

Mitochondrial diseases (encephalomyopathies) have traditionally been ascribed to defects
of the respiratory chain, which has helped researchers explain their genetic and clinical …