Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Objective Complex local crosstalk amongst endocrine cells within the islet ensures tight
coordination of their endocrine output. This is illustrated by the recent demonstration that the …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Recently, loss of beta-cell-specific traits has been proposed as an early cause of beta cell
failure in diabetes. However, the molecular mechanisms that underlie the loss of beta cell …

The interaction between the immune system and endocrine cells in the pancreas is crucial
for the initiation and progression of type 1 diabetes (T1D). Imaging mass cytometry (IMC) …

Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant
glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The …

Background Insulin producing beta cell and glucagon producing alpha cells are colocalized
in pancreatic islets in an arrangement that facilitates the coordinated release of the two …

Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing
α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it …