Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

Statistical considerations in reporting cardiovascular research

ML Lindsey, GA Gray, SK Wood… - American Journal of …, 2018 - journals.physiology.org
The problem of inadequate statistical reporting is long standing and widespread in the
biomedical literature, including in cardiovascular physiology. Although guidelines for …

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

TS Shankar, DKA Ramadurai, K Steinhorst… - Nature …, 2021 - nature.com
Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin
known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium …

Interventricular differences of signaling pathways-mediated regulation of cardiomyocyte function in response to high oxidative stress in the post-ischemic failing rat …

Á Kovács, M Herwig, H Budde, S Delalat, D Kolijn… - Antioxidants, 2021 - mdpi.com
Standard heart failure (HF) therapies have failed to improve cardiac function or survival in
HF patients with right ventricular (RV) dysfunction suggesting a divergence in the molecular …

Essential role of ryanodine receptor 2 phosphorylation in the effect of azumolene on ventricular arrhythmia vulnerability in a rabbit heart model

D Si, MA Azam, PFH Lai, N Zamiri… - Journal of …, 2018 - Wiley Online Library
Introduction Following long‐duration ventricular fibrillation (LDVF), reinitiation of ventricular
fibrillation (VF) poses a major challenge during resuscitation. Ryanodine receptor 2 (RyR2) …

Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression

X Chen, C Zhang, Y Guo, X Liu, T Ye, Y Fo, C Qu… - Life Sciences, 2020 - Elsevier
Aim The purpose of the study was to investigate what effects the sigma-1 receptor (S1R)
could exert on the cardiac myocyte ion channels in a rodent model of depression and to …

Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension

X Sun, J Cao, Z Chen, Y Liu, JL VonCannon, HJ Cheng… - Heliyon, 2023 - cell.com
Abstract Aims Upregulation of Ca 2+/calmodulin-dependent protein kinase II (CaMKII)
contributes to the pathogenesis of cardiovascular disease, including hypertension …

Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis

AV Zaitsev, NS Torres, KM Cawley… - American Journal …, 2019 - journals.physiology.org
The “stress” kinases cAMP-dependent protein kinase (PKA) and calcium/calmodulin-
dependent protein kinase II (CaMKII), phosphorylate the Na+ channel Nav1. 5 subunit to …

Regulatory mechanism of calcium/calmodulin‑dependent protein kinase II in the occurrence and development of ventricular arrhythmia

K Ma, G Ma, Z Guo, G Liu… - Experimental and …, 2021 - spandidos-publications.com
Ventricular arrhythmia (VA) is a highly fatal arrhythmia that involves multiple ion channels. Of
all sudden cardiac death events,~ 85% result from VAs, including ventricular tachycardia …

CaMKII blockade, cardiac conduction, and arrhythmia

M Warren, AV Zaitsev - Cardiovascular Research, 2017 - academic.oup.com
We have read the study by Takanari et al. 1 published in Cardiovascular Research with
interest, all the more so given that the reported results are in stark contrast with our own …