Methods: This review aims to provide an interdisciplinary overview of recent evidence-based
and clinical knowledge. Results: The scientific evidence for best practice is weak and …

The emerging roles of ketamine and esketamine as effective rapid-acting antidepressants
hold promise for patients suffering from treatment-resistant depression and/or major …

Ketamine produces antidepressant effects in patients with treatment-resistant depression,
but its usefulness is limited by its psychotropic side effects. Ketamine is thought to act via …

Ketamine is a racemic mixture of equal amounts of R-ketamine and S-ketamine and is well
known to anesthesiologists for its unique dissociative anesthetic properties. The …

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …

Background: Ketamine produces potent analgesia combined with psychedelic effects. It has
been suggested that these two effects are associated and possibly that analgesia is …

A coherent sense of self is crucial for social functioning and mental health. The N-methyl-D-
aspartate antagonist ketamine induces short-term dissociative experiences and has …

ABSTRACT A diverse array of studies has been devoted to understanding the
neurochemical systems supporting responsiveness to hypnotic suggestions, with …

Mounting evidence suggests an association between aberrant sleep phenomena and
dissociative experiences. However, no wake–sleep boundary theory provides a compelling …

Background Chronic ketamine use leads to cognitive impairments, however, the neural
mechanisms underpinning these impairments are still unclear. Aims Many studies showed …