Simple Summary Anoikis is a programmed cell death process resulting from the loss of
interaction between cells and the extracellular matrix. Therefore, it is necessary to overcome …

Antibody-drug conjugates (ADCs) are cancer therapeutic agents comprised of an antibody,
a linker and a small-molecule payload. ADCs use the specificity of the antibody to target the …

Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …

The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of …