[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …
(PACAP) are members of a superfamily of structurally related peptide hormones that …
VPAC and PAC receptors: from ligands to function
L Dickson, K Finlayson - Pharmacology & therapeutics, 2009 - Elsevier
Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating
polypeptides (PACAPs) share 68% identity at the amino acid level and belong to the …
polypeptides (PACAPs) share 68% identity at the amino acid level and belong to the …
Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR
Molecular determinants regulating the activation of class B G-protein-coupled receptors
(GPCRs) by native peptide agonists are largely unknown. We have investigated here the …
(GPCRs) by native peptide agonists are largely unknown. We have investigated here the …
Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology
M Laburthe, A Couvineau, V Tan - Peptides, 2007 - Elsevier
VIP and PACAP impact strongly on human pathophysiology. Their receptors are very
promising targets for developing new drugs in the treatment of inflammatory and …
promising targets for developing new drugs in the treatment of inflammatory and …
Activation of G protein–coupled receptors: beyond two-state models and tertiary conformational changes
PSH Park, DT Lodowski… - Annu. Rev. Pharmacol …, 2008 - annualreviews.org
Transformation of G protein–coupled receptors (GPCRs) from a quiescent to an active state
initiates signal transduction. All GPCRs share a common architecture comprising seven …
initiates signal transduction. All GPCRs share a common architecture comprising seven …
VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins
A Couvineau, M Laburthe - British journal of pharmacology, 2012 - Wiley Online Library
The vasoactive intestinal peptide (VIP) is a neuropeptide with wide distribution in both
central and peripheral nervous systems, where it plays important regulatory role in many …
central and peripheral nervous systems, where it plays important regulatory role in many …
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS
C Sun, D Song, RA Davis-Taber… - Proceedings of the …, 2007 - National Acad Sciences
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G
protein-coupled receptor that contributes to many different cellular functions including …
protein-coupled receptor that contributes to many different cellular functions including …
Transmembrane signal transduction by peptide hormones via family BG protein-coupled receptors
Although family BG protein-coupled receptors (GPCRs) contain only 15 members, they play
key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug …
key roles in transmembrane signal transduction of hormones. Family B GPCRs are drug …
Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain
S Runge, S Schimmer, J Oschmann, CB Schiødt… - Biochemistry, 2007 - ACS Publications
Glucagon-like peptide-1 (GLP-1) and exendin-4 (Ex4) are homologous peptides with
established potential for treatment of type 2 diabetes. They bind and activate the pancreatic …
established potential for treatment of type 2 diabetes. They bind and activate the pancreatic …