Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many
substantia nigra (SN) dopamine neurons have already died. Now that therapies to block this …

Abstract Models of cognitive function typically focus on the cerebral cortex and hence
overlook functional links to subcortical structures. This view does not consider the role of the …

The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and
memory. Here we begin with an overview of the LC-NE system. We then consider how both …

Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …

For decades, research into memory decline in human cognitive ageing has focused on
neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …

Alzheimer's disease neurodegeneration is thought to spread across anatomically and
functionally connected brain regions. However, the precise sequence of spread remains …

The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous
system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders …