Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

High-grade prostatic intraepithelial neoplasia (PIN) is now accepted as the most likely
preinvasive stage of adenocarcinoma, almost two decades after its first formal description …

To determine the role of telomere dysfunction and telomerase reactivation in generating pro-
oncogenic genomic events and in carcinoma progression, an inducible telomerase reverse …

Purpose: Telomeres help maintain chromosomal integrity. Dysfunctional telomeres can
cause genetic instability in vitro and an increased cancer incidence in telomerase knock out …

Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …

Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or
prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of …

Prostatic intraepithelial neoplasia (PIN) is the most established precursor of prostatic
carcinoma. The presence of prominent nucleoli within an existing duct structure is an easy …

Bostwick DG & Cheng L (2012) Histopathology 60, 4–27 Precursors of prostate cancer High‐
grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic …

Prostate cancer often manifests as morphologically distinct tumour foci and is frequently
found adjacent to presumed precursor lesions such as high‐grade prostatic intraepithelial …