Revolutionizing medical implant fabrication: advances in additive manufacturing of biomedical metals

Y Li, D Jiang, R Zhu, C Yang, L Wang… - International Journal of …, 2024 - iopscience.iop.org
Additive manufacturing has emerged as a transformative technology for producing
biomedical metals and implants, offering the potential to revolutionize patient care and …

Materials Strategies to Overcome the Foreign Body Response

X Zhou, Y Wang, J Ji, P Zhang - Advanced Healthcare …, 2024 - Wiley Online Library
The foreign body response (FBR) is an immune‐mediated reaction that can occur with most
biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of …

Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels

Z Liu, X Zhou, Y Chen, Y Ni, Z Zhu, W Cao… - Biomaterials …, 2024 - pubs.rsc.org
Foreign body response (FBR) represents an immune-mediated cascade reaction capable of
inducing the rejection of foreign implants, thereby compromising their in vivo performance …

Immunocompatible elastomer with increased resistance to the foreign body response

X Zhou, Z Lu, W Cao, Z Zhu, Y Chen, Y Ni, Z Liu… - Nature …, 2024 - nature.com
Polymeric elastomers are extensively employed to fabricate implantable medical devices.
However, implantation of the elastomers can induce a strong immune rejection known as the …

Antifouling Immunomodulatory Copolymer Architectures That Inhibit the Fibrosis of Implants

WJ Jeang, BM Wong, Y Zhao, RS Manan… - Advanced …, 2024 - Wiley Online Library
Immune reactions to medical implants often lead to encapsulation by fibrotic tissue and
impaired device function. This process is thought to initiate by protein adsorption, which …

[HTML][HTML] The Deposition of Hydroxyapatite Particles Within an Organic Matrix on the Surface of Poly (lactic acid)

K Dopierała, E Krok, E Stachowska… - International Journal of …, 2024 - mdpi.com
Hydroxyapatite (HAP) is a well-established material in biomedical applications, especially
for bone tissue regeneration, dental implants, and drug delivery systems. Recent research …

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids

W Suvannapruk, LE Fisher, JC Luckett… - Advanced …, 2024 - Wiley Online Library
A key goal for implanted medical devices is that they do not elicit a detrimental immune
response. Macrophages play critical roles in the modulation of the host immune response …

[HTML][HTML] Fucoidan alginate and sulfated alginate microbeads induce distinct coagulation, inflammatory and fibrotic responses.

K Vasuthas, JS Kjesbu, A Brambilla, M Levitan… - Materials Today Bio, 2025 - Elsevier
This study investigates the host response to fucoidan alginate microbeads in comparison to
sulfated alginate microbeads, which are relevant for immune protection in cell therapy. While …

[HTML][HTML] Immunomodulatory hydrogels for tissue repair and regeneration

X Liu, Y Hu, Y Ju, P Yang, N Shen, A Yang, R Wu… - APL Materials, 2024 - pubs.aip.org
Tissue repair and regeneration have long been a focus of research, with growing evidence
highlighting the role played by immunomodulation. The repair of tissue cells can be …

Small molecule conjugation reduces macrophage uptake and increases in vivo blood circulation of polystyrene nanoparticles

D Yenurkar, M Ruocco, L Liang… - Biomedical …, 2024 - iopscience.iop.org
Nanomedicine often failed clinically to show therapeutic efficacy due to reduced particle
circulation and enhanced capture by the reticuloendothelial system, including the liver …