The immunosuppressive activity of artemisinin‐type drugs towards inflammatory and autoimmune diseases

T Efferth, F Oesch - Medicinal research reviews, 2021 - Wiley Online Library
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

[HTML][HTML] Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy

Y Chen, S Shi, Y Dai - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …

[HTML][HTML] Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …

[HTML][HTML] Polychemotherapy with curcumin and doxorubicin via biological nanoplatforms: enhancing antitumor activity

M Ashrafizadeh, A Zarrabi, F Hashemi, A Zabolian… - Pharmaceutics, 2020 - mdpi.com
Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

[HTML][HTML] Codelivery of phytochemicals with conventional anticancer drugs in form of nanocarriers

G Kumar, T Virmani, A Sharma, K Pathak - Pharmaceutics, 2023 - mdpi.com
Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the
heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various …

Curcumin ameliorates doxorubicin-induced cardiotoxicity and hepatotoxicity via suppressing oxidative stress and modulating iNOS, NF-κB, and TNF-α in rats

G Ibrahim Fouad, KA Ahmed - Cardiovascular toxicology, 2022 - Springer
Doxorubicin (DOX) is one of the widely used anti-tumor drugs. However, DOX-induced
cardiotoxicity (DIC) and hepatotoxicity (DIH) are among the side effects that limited its …

Natural bioactive compounds-doxorubicin combinations targeting topoisomerase II-alpha: Anticancer efficacy and safety

A Elfadadny, RF Ragab, R Hamada… - Toxicology and Applied …, 2023 - Elsevier
Cancer is one of the leading causes of death worldwide, so pursuing effective and safe
therapeutics for cancer is a key research objective nowadays. Doxorubicin (DOX) is one of …

[HTML][HTML] An overview of the enhanced effects of curcumin and chemotherapeutic agents in combined cancer treatments

NA Cacciola, R Cuciniello, GD Petillo… - International Journal of …, 2023 - mdpi.com
Due to the progressive ageing of the human population, the number of cancer cases is
increasing. For this reason, there is an urgent need for new treatments that can prolong the …

Improved efficacy of doxorubicin delivery by a novel dual-ligand-modified liposome in hepatocellular carcinoma

X Li, W Diao, H Xue, F Wu, W Wang, B Jiang, J Bai… - Cancer letters, 2020 - Elsevier
Liposomes have been widely used as drug carriers in both biomedical research and for
clinical applications, allowing the stabilisation of therapeutic compounds and overcoming …

[HTML][HTML] Mokko lactone attenuates doxorubicin-induced hepatotoxicity in rats: Emphasis on Sirt-1/FOXO1/NF-κB axis

A Sirwi, RA Shaik, AJ Alamoudi, BG Eid, AK Kammoun… - Nutrients, 2021 - mdpi.com
Doxorubicin (DOX), a common chemotherapeutic agent, suffers serious adverse effects
including hepatotoxicity. Mokko lactone (ML) is a guainolide sesquiterpene with promising …