Tissue factor in cancer-associated thromboembolism: possible mechanisms and clinical applications

S Koizume, Y Miyagi - British Journal of Cancer, 2022 - nature.com
Venous and arterial thromboses, called as cancer-associated thromboembolism (CAT), are
common complications in cancer patients that are associated with high mortality. The cell …

Antithrombotic treatment in coronary artery disease

G Siasos, V Tsigkou, E Bletsa… - Current …, 2023 - benthamdirect.com
Coronary artery disease exhibits growing mortality and morbidity worldwide despite the
advances in pharmacotherapy and coronary intervention. Coronary artery disease is …

Platelet Membrane Cloaked Nanotubes to Accelerate Thrombolysis by Thrombus Clot‐Targeting and Penetration

B Liu, F Victorelli, Y Yuan, Y Shen, H Hong, G Hou… - Small, 2023 - Wiley Online Library
Thrombotic diseases have a high rate of mortality and disability, and pose a serious threat to
global public health. Currently, most thrombolytic drugs especially protein drugs have a …

Universal EHRs clinical decision support for thromboprophylaxis in medical inpatients: a cluster randomized trial

AC Spyropoulos, M Goldin, I Koulas, J Solomon, M Qiu… - JACC: Advances, 2023 - jacc.org
Background Thromboprophylaxis for medically ill patients during hospitalization and
postdischarge remains underutilized. Clinical decision support (CDS) may address this …

To prophylax or not, and how much and how long? Controversies in VTE prevention for medical inpatients, including COVID-19 inpatients

AC Spyropoulos - Hematology, 2022 - ashpublications.org
The field of thromboprophylaxis for acutely ill medical patients, including those hospitalized
for COVID-19, is rapidly evolving both in the inpatient setting and the immediate post …

Venous Thromboembolism in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis of 4,170,027 Patients

D Pastori, G Gazzaniga, A Farcomeni, T Bucci… - JACC: Advances, 2023 - jacc.org
Background Data on the association between atrial fibrillation (AF) and venous
thromboembolism (VTE) are controversial. Objectives The purpose of this study was to …

Factor XIa Inhibition: Is It a Novel Alternative Antithrombotic Strategy for High-Risk ACS Patients?

YX Gue, DA Gorog, GYH Lip - Circulation, 2022 - Am Heart Assoc
Despite revascularization and optimal secondary prevention, including dual antiplatelet
therapy (DAPT), patients with acute coronary syndrome (ACS) remain at risk of recurrent …

Exploring the therapeutic utility of the factor XIa inhibitor asundexian

J Edwards, J Corey, JC Coons - American Journal of Health …, 2024 - academic.oup.com
Abstract Purpose Factor XIa inhibitors are a promising novel class of anticoagulants that
attenuate pathological thrombosis with minimal interference with hemostasis. These effects …

Dual Antiplatelet Therapy or Dual Pathway Inhibition

S Goto, S Goto - Thrombosis and Haemostasis, 2024 - thieme-connect.com
Both antiplatelet and anticoagulation therapies have a unique history of preventing acute
myocardial infarction. A landmark randomized clinical trial, namely ISIS-2, had a strong …

Integrin β Expression as a New Diagnostic Marker for Arteriovenous Thrombosis: A Single-Center Prospective Study

Y Xi, Y Mao, F Yang, P Xi, W Zhu, Y Song… - Journal of …, 2023 - mdpi.com
Integrin β plays an important role in the pathogenesis of thrombosis and inflammation, and it
may be a shared pathogenic mechanism between arterial and venous thromboses. With the …