27-Hydroxycholesterol (27-HC) is the most abundant oxysterol that increases the risk of
breast cancer progression. However, little is known about epigenetic regulation of 27-HC …

Abstract Background 27-hydroxycholesterol (HC) and 25-HC were identified as endogenous
selective estrogen receptor modulators (SERMs) and estrogen receptor (ER) modulators …

Cancer has become a serious health burden that results in high incidence and mortality
rates every year, mainly due to various molecular alterations inside the cell. Liver X …

Bladder cancer (BCa) is a common malignancy with uncertain molecular mechanism. 7-
dehydrocholesterol reductase (DHCR7), the enzyme of mammalian sterol biosynthesis …

In melanoma, predicting which tumors will ultimately metastasize guides treatment
decisions. Transcriptional signatures of primary tumors have been utilized to predict …

Although survival from breast cancer has dramatically increased, many will develop
recurrent, metastatic disease. Unfortunately, survival for this stage of disease remains very …

Immune checkpoint blockade (ICB) has had limited utility in several solid tumors such as
breast cancer, a major cause of cancer-related mortality in women. Therefore, there is …

Immune checkpoint blockade (ICB) has revolutionized cancer therapy but has had limited
utility in several solid tumors such as breast cancer, a major cause of cancer-related …

Small extracellular vesicles (sEVs) are emerging as critical mediators of intercellular
communication in the tumor microenvironment (TME). Here, we investigate the mechanisms …