The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance–A focus on signaling pathways interplay

M Hegazy, MA Elkady, AM Yehia, EGE Elsakka… - … -Research and Practice, 2023 - Elsevier
Laryngeal cancer (LC) is the malignancy of the larynx (voice box). The majority of LC are
squamous cell carcinomas. Many risk factors were reported to be associated with LC as …

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

AJ Schetter, NHH Heegaard, CC Harris - Carcinogenesis, 2010 - academic.oup.com
Chronic inflammation and infection are major causes of cancer. There are continued
improvements to our understanding of the molecular connections between inflammation and …

[PDF][PDF] Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

JC Mossanen, O Krenkel, C Ergen, O Govaere… - …, 2016 - Wiley Online Library
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …

Silencing of microRNA families by seed-targeting tiny LNAs

S Obad, CO dos Santos, A Petri, M Heidenblad… - Nature …, 2011 - nature.com
The challenge of understanding the widespread biological roles of animal microRNAs
(miRNAs) has prompted the development of genetic and functional genomics technologies …

Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21

ME Hatley, DM Patrick, MR Garcia, JA Richardson… - Cancer cell, 2010 - cell.com
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell
lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is …

MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

J Zhang, J Wang, F Zhao, Q Liu, K Jiang, G Yang - Clinica chimica acta, 2010 - Elsevier
BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating
gene expression that play roles in the pathogenesis of human diseases, including …

[HTML][HTML] Apoptosis and the target genes of microRNA-21

LEB Buscaglia, Y Li - Chinese journal of cancer, 2011 - ncbi.nlm.nih.gov
Abstract MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majority of its
reported targets are tumor suppressors. Through functional suppression, miR-21 is …

MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy

WCS Cho - The international journal of biochemistry & cell biology, 2010 - Elsevier
MicroRNAs have a revolutionary impact on cancer research over recent years. They emerge
as important players in tumorigenesis, leading to a paradigm shift in oncology. The …

Traumatic brain injury: classification, models, and markers

D Najem, K Rennie… - … and cell biology, 2018 - cdnsciencepub.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. Due to
its high incidence rate and often long-term sequelae, TBI contributes significantly to …

A novel miR‐155/miR‐143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells

S Jiang, LF Zhang, HW Zhang, S Hu, MH Lu… - The EMBO …, 2012 - embopress.org
Cancer cells preferentially metabolize glucose through aerobic glycolysis. This
phenomenon, known as the Warburg effect, is an anomalous characteristic of glucose …