Recent discoveries on the involvement of Krüppel-like factor 4 in the most common cancer types

A Taracha-Wisniewska, G Kotarba, S Dworkin… - International Journal of …, 2020 - mdpi.com
Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is
particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays …

RNA-binding protein signaling in adult neurogenesis

JNM Chan, DI Sánchez-Vidaña… - Frontiers in Cell and …, 2022 - frontiersin.org
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival,
and maturation, results in the formation of new functional neurons. During embryonic …

lncRNA LINC00665 stabilized by TAF15 impeded the malignant biological behaviors of glioma cells via STAU1-mediated mRNA degradation

X Ruan, J Zheng, X Liu, Y Liu, L Liu, J Ma, Q He… - … Therapy-Nucleic Acids, 2020 - cell.com
Glioma is a brain cancer characterized by strong invasiveness with limited treatment options
and poor prognosis. Recently, dysregulation of long non-coding RNAs (lncRNAs) has …

CSN6 mediates nucleotide metabolism to promote tumor development and chemoresistance in colorectal cancer

S Zou, B Qin, Z Yang, W Wang, J Zhang, Y Zhang… - Cancer Research, 2023 - AACR
Metabolic reprogramming can contribute to colorectal cancer progression and therapy
resistance. Identification of key regulators of colorectal cancer metabolism could provide …

Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor–mediated mRNA decay

H Zhu, J Li, Y Li, Z Zheng, H Guan, H Wang, K Tao… - Science …, 2021 - science.org
Mechanical stimuli on cells and mechanotransduction are essential in many biological and
pathological processes. Glucocorticoid is an important hormone, roles, and mechanisms of …

The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

S Almasi, BJ Jasmin - Cellular and Molecular Life Sciences, 2021 - Springer
The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially
discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs …

KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure

J Bi, W Wang, M Zhang, B Zhang, M Liu… - Nucleic acids …, 2022 - academic.oup.com
Neural differentiation of embryonic stem cells (ESCs) requires precisely orchestrated gene
regulation, a process governed in part by changes in 3D chromatin structure. How these …

NF-κB-activated SPRY4-IT1 promotes cancer cell metastasis by downregulating TCEB1 mRNA via Staufen1-mediated mRNA decay

L Zhao, L Jiang, M Zhang, Q Zhang, Q Guan, Y Li… - Oncogene, 2021 - nature.com
Previous study demonstrated that most long non-coding RNAs (lncRNAs) function as
competing endogenous RNAs or molecular sponges to negatively modulate miRNA and …

IGF2BP2 stabilized FBXL19-AS1 regulates the blood-tumour barrier permeability by negatively regulating ZNF765 by STAU1-mediated mRNA decay

X Liu, P Wu, R Su, Y Xue, C Yang, D Wang, X Ruan… - RNA biology, 2020 - Taylor & Francis
Blood-tumour barrier (BTB) has been known to significantly attenuate the efficacy of
chemotherapy for glioma. In this report, we identified that insulin-like grown factor 2 mRNA …

Role of circular RNA expression in the pathological progression after spinal cord injury

WZ Wang, J Li, L Liu, ZD Zhang, MX Li… - Neural Regeneration …, 2021 - journals.lww.com
Differential expression of non-coding RNA after traumatic spinal cord injury (TSCI) is closely
related to the pathophysiological process. The purposes of this study were to systematically …