Tumor necrosis factor alpha (TNF-α) is a pleiotropic inflammatory cytokine. The cytokine
possesses both growth stimulating properties and growth inhibitory processes, and it …

The synthesis of new polyamine derivatives containing dimeric quinoline (3a–c), cinnoline
(4a–c) and phthalimide (7a–c and 8a–c) moieties is described. Three different …

The present work reports the synthesis and evaluation of the antitumour and
immunomodulatory properties of new phthalimides derivatives designed to explore …

The strategy of antiangiogenic drugs is based on inhibiting formation of new blood vessels
as alternative to limit cancer progression. In this work, we investigated the antitumor and …

Discovery of phthalimides as immunomodulatory and antitumor drug prototypes Discovery of
phthalimides as immunomodulatory and antitumor drug prototypes ChemMedChem. 2010 Apr …

Thalidomide is a tumor necrosis factor alpha (TNF-α) inhibitor which has been found to have
abilities against tumor growth, inflammation. QSAR studies have been performed on twenty …

A new series of imide derivatives related to thalidomide were synthesized and evaluated as
modulators of TNF-α production. These derivatives enhance TNF-α production using human …

Thalidomide is used to treat a variety of diseases including erythema nodosum leprosum, an
inflammatory complication of leprosy. However, this drug has severe teratogenic activity and …

The reintroduction of thalidomide in the pharmacotherapy greatly stimulated the interest in
the synthesis and pharmacological evaluation of phthalimide analogs with new and …

Alders exhibit several uses in different areas and also offer some nutritional and medicinal
values. The bark and leaves from black alder [Alnus glutinosa (L.) Gaertn] are used in folk …