A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

This review summarizes the importance and recent discoveries of the use of adamantane
derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) …

Neglected tropical diseases cause significant morbidity and mortality and are a source of
poverty in endemic countries. Only a few drugs are available to treat diseases such as …

Chemotherapy and chemoprophylaxis of influenza is one of the most important directions of
health protection activity. Due to the high rate of drug-resistant strains of influenza virus …

Reliable regio-and stereochemical techniques applicable to nonactivated aliphatic systems
remain largely elusive due to the challenges of discriminating between multiple, relatively …

Amantadine has been used for decades as an inhibitor of the influenza A virus M2 protein
(AM2) in the prophylaxis and treatment of influenza A infections, but its clinical use has been …

Amantadine inhibits the M2 proton channel of influenza A virus, yet its clinical use has been
limited by the rapid emergence of amantadine-resistant virus strains. We have synthesized …

The influenza A virus contains a proton-selective ion channel (M2) that is the target of the
adamantane family of drug inhibitors. Two recently published studies relating to …

1–2 Annulated adamantane piperidines 4, 6, 16, 17, 19, 23 and 25 were synthesized and
evaluated for anti-influenza A virus activity. The stereoelectronic requirements for optimal …

Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but
the most frightening effects are seen when new strains of the virus emerge from different …