The phenomenon of a gene expression burst has been attributed to random transitions
between the active and inactive states of a gene. However, the mechanisms underlying …

Gene transcription is a stochastic process manifested by fluctuations in mRNA copy
numbers in individual isogenic cells. Together with mathematical models of stochastic …

Motivation Gene transcription is a random and noisy process. Tremendous efforts in single-
cell studies have been mapping transcription noises to phenotypic variabilities between …

Gene transcription is a noisy process, and cell division cycle is an important source of gene
transcription noise. In this work, we develop a mathematical approach by coupling …

Gene transcription is a stochastic process, and is often activated by multiple signal
transduction pathways. In this work, we study gene transcription activated randomly by two …

Gene transcription is a central process in life. In single cells, it is a random process since
many regulatory molecules are present at low copy numbers. The randomness is best …

Randomness in gene transcription can result in fluctuations (noise) of messenger RNA
(mRNA) levels, leading to phenotypic plasticity in the isogenic populations of cells. Recent …

The periodic transcription output is ubiquitously observed in an isogenic cell population. To
understand mechanisms of cyclic behavior in transcription, we extend the gene activation …

Life growth and development are driven by continuous cell divisions. Cell division is a
stochastic and complex process. In this paper, we study the impact of cell division on the …

Gene expression is the central process in cells, and is stochastic in nature. In this work, we
study the mean expression level of, and the expression noise in, a population of isogenic …