Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that
play a central role in host cell recognition and responses to microbial pathogens. TLR …

Candida albicans is a common fungal pathogen of humans that colonizes the skin and
mucosal surfaces of most healthy individuals. Until recently, little was known about the …

Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet
the mechanisms of action are largely unknown. Here we showed that type I IFN inhibited …

Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …

The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …

Induction, production, and release of proinflammatory cytokines are essential steps to
establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce …

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved
in innate immune responses to fungal pathogens. This transmembrane signalling receptor …

Abstract β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its
importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the …

Production of the proinflammatory cytokine interleukin 1β (IL-1β) by dendritic cells is crucial
in host defense. Here we identify a previously unknown role for dectin-1 in the activation of a …