Genetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource-limited sub-Saharan Africa?

TO Apinjoh, A Ouattara, VPK Titanji, A Djimde… - Malaria journal, 2019 - Springer
The intensification of malaria control interventions has resulted in its global decline, but it
remains a significant public health burden especially in sub-Saharan Africa (sSA) …

Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda

V Asua, MD Conrad, O Aydemir… - The Journal of …, 2021 - academic.oup.com
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors

M Ocan, D Akena, S Nsobya, MR Kamya, R Senono… - Malaria journal, 2019 - Springer
Background Chloroquine, a previous highly efficacious, easy to use and affordable anti-
malarial agent was withdrawn from malaria endemic regions due to high levels of …

Drug resistance of Plasmodium falciparum and Plasmodium vivax isolates in Indonesia

FV Rahmasari, PBS Asih, FK Dewayanti… - Malaria Journal, 2022 - Springer
This review article aims to investigate the genotypic profiles of Plasmodium falciparum and
Plasmodium vivax isolates collected across a wide geographic region and their association …

Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

DM Wakoli, BN Ondigo, DO Ochora, JG Amwoma… - BMC medicine, 2022 - Springer
Abstract Background Dihydroartemisinin-piperaquine (DHA-PPQ) is an alternative first-line
antimalarial to artemether-lumefantrine in Kenya. However, recent reports on the emergence …

pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies

JP Gil, S Krishna - Expert review of anti-infective therapy, 2017 - Taylor & Francis
Introduction: Plasmodium falciparum, the deadly agent of malaria, is notorious for its
capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens …

Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa

AN Wotodjo, MA Oboh, S Doucoure, N Diagne… - Malaria journal, 2023 - Springer
Background Thanks to the scale up of malaria control interventions, the malaria burden in
Senegal has decreased substantially to the point that the National Malaria Control …

[HTML][HTML] Impacts of antimalarial drugs on Plasmodium falciparum drug resistance markers, Western Kenya, 2003–2015

E Hemming-Schroeder, E Umukoro, E Lo… - The American journal …, 2018 - ncbi.nlm.nih.gov
Antimalarial drug resistance has threatened global malaria control since chloroquine (CQ)-
resistant Plasmodium falciparum emerged in Asia in the 1950s. Understanding the impacts …

Comparative efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Ugandan children

A Yeka, E Wallender, R Mulebeke… - The Journal of …, 2019 - academic.oup.com
Abstract Background In Uganda, artemether-lumefantrine (AL) and dihydroartemisinin-
piperaquine (DHA-PQ) showed excellent treatment efficacy for uncomplicated malaria in …

Seasonal Malaria Chemoprevention with Sulphadoxine-Pyrimethamine and Amodiaquine Selects Pfdhfr-dhps Quintuple Mutant Genotype in Mali

H Maiga, E Lasry, M Diarra, I Sagara, A Bamadio… - PLoS …, 2016 - journals.plos.org
Background Seasonal malaria chemoprevention (SMC) with sulphadoxine-pyrimethamine
(SP) plus amodiaquine (AQ) is being scaled up in Sahelian countries of West Africa …