Liver sinusoidal endothelial cells—gatekeepers of hepatic immunity
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver
AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair
B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …
[HTML][HTML] Disruption of central nervous system barriers in multiple sclerosis
The delicate microenvironment of the central nervous system (CNS) is protected by the
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …
blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers …
Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis
CJ Weston, EL Shepherd, LC Claridge… - The Journal of …, 2015 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) encompasses a range of manifestations, including
steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte …
steatosis and cirrhosis. Progressive disease is characterized by hepatic leukocyte …
[PDF][PDF] Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
Liver fibrosis is a wound healing response to chronic liver injury and inflammation in which
macrophages and infiltrating monocytes participate in both the development and resolution …
macrophages and infiltrating monocytes participate in both the development and resolution …
Mechanisms of immune-mediated liver injury
DH Adams, C Ju, SK Ramaiah, J Uetrecht… - Toxicological …, 2010 - academic.oup.com
Hepatic inflammation is a common finding during a variety of liver diseases including drug-
induced liver toxicity. The inflammatory phenotype can be attributed to the innate immune …
induced liver toxicity. The inflammatory phenotype can be attributed to the innate immune …
Challenges and opportunities in achieving effective regulatory T cell therapy in autoimmune liver disease
Autoimmune liver diseases (AILD) include autoimmune hepatitis (AIH), primary biliary
cholangitis (PBC) and primary sclerosing cholangitis (PSC). These immune-mediated liver …
cholangitis (PBC) and primary sclerosing cholangitis (PSC). These immune-mediated liver …
The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions
Metabolic dysfunction-associated fatty liver disease (MAFLD), proposed in 2020 is a novel
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …
Vascular adhesion protein-1: a cell surface amine oxidase in translation
M Salmi, S Jalkanen - Antioxidants & redox signaling, 2019 - liebertpub.com
Abstract Significance: Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that oxidates
primary amines in a reaction producing also hydrogen peroxide. VAP-1 on the blood vessel …
primary amines in a reaction producing also hydrogen peroxide. VAP-1 on the blood vessel …