The pathological aggregation and misfolding of tau and amyloid-β play a key role in
Alzheimer's disease (AD). However, the underlying pathological mechanisms remain …

Soluble amyloid-β oligomers (AβOs) are proposed to instigate and mediate the pathology of
Alzheimer's disease, but the mechanisms involved are not clear. In this study, we reported …

The intricate organization of distinct cellular compartments is paramount for the maintenance
of normal biological functions and the orchestration of complex biochemical reactions …

The nucleocapsid (N) protein is an essential structural component necessary for genomic
packaging and replication in various human coronaviruses (HCoVs), such as SARS‐CoV‐2 …

The formation of biomolecular condensates in vivo is increasingly recognized to underlie a
multitude of crucial cellular functions. Furthermore, the evolution of highly dynamic protein …

Hsp90α, a pivotal canonical chaperone, is renowned for its broad interaction with numerous
protein clients to maintain protein homeostasis, chromatin remodeling, and cell growth …

蛋白质的错误折叠和聚集与一系列神经退行性疾病密切相关, 比如阿尔茨海默病, 帕金森病等,
其主要病理特征是以蛋白质异常聚集形成的淀粉样纤维为主要成分的包涵体 …

Protein liquid–liquid phase separation (LLPS) is a significant process in biology and
material sciences. Finding suitable conditions for protein LLPS is essential for its in-depth …

Background Liquid–liquid phase separation (LLPS) by biomolecules plays a central role in
various biological phenomena and has garnered significant attention. The behavior of LLPS …

Phase separation is a common biological phenomenon in the liquid environment of
organisms. Phase separation has been shown to be a key cause of many existing incurable …