Early and accurate diagnosis of Creutzfeldt–Jakob disease (CJD) is a necessary to
distinguish this untreatable disease from treatable rapidly progressive dementias, and to …

Rapidly progressive dementia mimicking Creutzfeldt–Jakob disease (CJD) is a relatively
rare presentation but a rewarding one to become familiar with, as the potential diagnoses …

The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia
with Lewy bodies would be aided by the availability of assays for the pathogenic disease …

Importance Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is
necessary for quickly distinguishing treatable from untreatable rapidly progressive …

Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal
accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat …

The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer
disease and certain frontotemporal dementias is hampered by the inability to detect …

The development and adaption of in vitro misfolded protein amplification systems has been
a major innovation in the detection of abnormally folded prion protein scrapie (PrPSc) in …

In coping with prion diseases, it is important to have tests that are practical enough for
routine applications in medicine, agriculture, wildlife biology, and research, yet sensitive …

Rapid and sensitive detection of prions is important in managing prion diseases. The real-
time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been …

Protein amplification techniques exploit the ability of PrP TSE to induce a conformational
change in prion protein (PrP) in a continuous fashion, so that the small amount of PrP TSE …