Single cell genomics based insights into the impact of cell-type specific microbial internalization on disease severity

J Soni, R Pandey - Frontiers in Immunology, 2024 - frontiersin.org
Host-microbe interactions are complex and ever-changing, especially during infections,
which can significantly impact human physiology in both health and disease by influencing …

[HTML][HTML] Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery

S Yadav, P Mehta, J Soni, P Chattopadhyay, P Devi… - Iscience, 2023 - cell.com
Intracellular microorganisms, like viruses, bacteria, and fungi, pose challenges in detection
due to their non-culturable forms. Transcriptomic analysis at cellular level enables …

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)

D Venkatesan, S Muthukumar, M Iyer… - … of Biochemical and …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which
eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely …

Dynamics of Whole Transcriptome Analysis (WTA) and Surface markers expression (AbSeq) in Immune Cells of COVID-19 Patients and Recovered captured through …

J Soni, P Chattopadhyay, P Mehta, R Mohite… - Frontiers in …, 2024 - frontiersin.org
Introduction Single-cell multi-omics studies, such as multidimensional transcriptomics
(whole transcriptomic analysis, WTA), and surface marker analysis (antibody sequencing …

[HTML][HTML] Disrupted gut microbiota aggravates spatial memory dysfunction induced by high altitude exposure: A link between plateau environment and microbiome–gut …

X Zhang, X Jia, S Wang, J Xin, N Sun, Y Wang… - Ecotoxicology and …, 2023 - Elsevier
Approximately 400 million people work and live in high-altitude areas and suffer from
memory dysfunction worldwide. Until now, the role of the intestinal flora in plateau-induced …

[HTML][HTML] Single cell and TCR analysis of immune cells from AAV gene therapy-dosed Duchenne muscular dystrophy patients

MR Emami, MA Brimble, A Espinoza, J Owens… - … Therapy Methods & …, 2024 - cell.com
Clinical trials for Duchenne muscular dystrophy (DMD) are assessing the therapeutic
efficacy of systemically delivered adeno-associated virus (AAV) carrying a modified DMD …

Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases

FE Agamah, THA Ederveen, M Skelton… - Frontiers in Molecular …, 2024 - frontiersin.org
Background COVID-19 disease is characterized by a spectrum of disease phases (mild,
moderate, and severe). Each disease phase is marked by changes in omics profiles with …

Dysregulated metal ion homeostasis underscores non-canonical function of CD8+ T cell during COVID-19

K Khare, P Chattopadhyay, P Devi, P Mehta… - Frontiers in …, 2023 - frontiersin.org
Introduction Several efforts have been made to describe the complexity of T cell
heterogeneity during the COVID-19 disease; however, there remain gaps in our …

Cell-specific housekeeping role of lncRNAs in COVID-19-infected and recovered patients

P Chattopadhyay, P Mehta, J Soni… - NAR Genomics and …, 2024 - academic.oup.com
A plethora of studies have demonstrated the roles of lncRNAs in modulating disease
severity and outcomes during infection. However, the spatio-temporal expression of these …

Recent infection with SARS‐CoV‐2 in donors was associated with a higher incidence of acute graft‐versus‐host disease in recipients undergoing allogeneic …

F Lin, L Xu, T Han, Z Xu, J Liu, Y He… - British Journal of …, 2024 - Wiley Online Library
The global pandemic has resulted in the common occurrence of SARS‐CoV‐2 infection in
the population. In the post‐pandemic era, it is imperative to understand the influence of …