Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

Voltage-gated calcium channels are well characterized at neuronal somata but less
thoroughly understood at the presynaptic terminal where they trigger transmitter release. In …

Calcium ions are ubiquitous intracellular mediators of numerous cellular processes. One of
the main mechanisms of Ca2+ entry into the cell involves the opening of Ca2+ channels in …

Trains of action potentials cause Ca2+-dependent facilitation and inactivation of presynaptic
P/Q-type Ca2+ channels that can alter synaptic efficacy. A potential mechanism for these …

Membrane depolarization and intracellular Ca2+ transients generated by activation of
voltage-gated Na+ and Ca2+ channels are local signals, which initiate physiological …

BACKGROUND: Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play
diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel …

Voltage‐dependent inactivation of calcium channels is a key mechanism for regulating
intracellular calcium levels and neuronal excitability. In sodium and potassium channels, the …

A new form of synaptic depression of excitatory synaptic transmission was observed when
making voltage-clamp recordings from large presynaptic terminals, the calyces of Held and …

Excitation-driven entry of Ca2+ through L-type voltage-gated Ca2+ channels controls gene
expression in neurons and a variety of fundamental activities in other kinds of excitable cells …