Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of
proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that …

The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus
(CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a
viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated …

Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E)
gene attenuates the virus. E gene encodes a small multifunctional protein that possesses …