Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

The complement system plays a major role in the autoimmune disease, systemic lupus
erythematosus (SLE). However, the role of complement in SLE is complex since it may both …

Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous
autoimmune disease. The etiology of lupus and the contribution of genetic, environmental …

Monogenic lupus is a form of systemic lupus erythematosus (SLE) that occurs in patients
with a single gene defect. This rare variant of lupus generally presents with early onset …

The complement system consists of effector proteins, regulators, and receptors that
participate in host defense against pathogens. Activation of the complement system, via the …

The complement system is an ancient and evolutionary conserved element of the innate
immune mechanism. It comprises of more than 20 serum proteins most of which are …

The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed
role of innate immune cells in this condition have dominated the field in the basic research …

A major function of the immune system is to protect the host from microbial infections. The
complement system plays important roles in both the innate and the adaptive immune …