Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum
protocol has been developed for application of neural stem/progenitor cells. In this regard …

Current methods for bioprinting functional tissue lack appropriate biofabrication techniques
to build complex 3D microarchitectures essential for guiding cell growth and promoting …

We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …

Traumatic spinal cord injury results in persistent disability due to disconnection of surviving
neural elements. Neural stem cell transplantation has been proposed as a therapeutic …

Because there is no curative treatment for spinal cord injury, establishing an ideal animal
model is important to identify injury mechanisms and develop therapies for individuals …

Stem cells play critical roles in cell therapies and tissue engineering for nerve repair.
However, achieving effective delivery of high cell density remains a challenge. Here, a novel …

NSI-566 is a stable, primary adherent neural stem cell line derived from a single human fetal
spinal cord and expanded epigenetically with no genetic modification. This cell line is being …

Spinal cord injury (SCI) produces both locomotor deficits and sensory dysfunction that
greatly reduce the overall quality of life. Mechanisms underlying chronic pain include …