The cytochromes P450 (P450s) are a broad class of heme b-containing mono-oxygenase
enzymes. The vast majority of P450s catalyse reductive scission of molecular oxygen using …

Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …

Abstract Vitamin B12 (cobalamin, Cbl) is required as a cofactor by two human enzymes, 5‐
methyltetrahydrofolate‐homocysteine methyltransferase (MTR) and methylmalonyl‐CoA …

Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR),
but there have been few studies of the interactions between these two proteins. In this study …

Abstract NAD (P) H-dependent electron-transfer (ET) systems require three functional
components: a flavin-containing NAD (P) H-dehydrogenase, one-electron carrier and metal …

Methionine synthase (MS) is a cobalamin-dependent enzyme. It transfers a methyl group
from methyltetrahydrofolate to homocysteine forming methionine and tetrahydrofolate. On …

Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …

Flavocytochrome P450 BM3 is a member of the diflavin reductase enzyme family. Members
include cytochrome P450 reductase, nitric-oxide synthase, methionine synthase reductase …

Human methionine synthase reductase (MSR) is a protein containing both FAD and FMN,
and it reactivates methionine synthase that has lost activity due to oxidation of cob (I) alamin …

The interaction between two members of the vitamin B group, vitamin B 2 (Riboflavin, Rib)
and vitamin B 12 (aquacobalamin, H 2 OCbl), was investigated in an aqueous solution by …