The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Chronic kidney disease (CKD) is a high-risk chronic catabolic disease due to its high
morbidity and mortality. CKD is accompanied by many complications, leading to a poor …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

Chronic kidney disease (CKD) is a public health problem driven by myofibroblast
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …

Acute kidney injury (AKI) is one of the main conditions responsible for chronic kidney
disease (CKD), including end-stage renal disease (ESRD) as a long-term complication …

Abstract Type 1 diabetes (T1D) is characterized by the progressive destruction of pancreatic
β-cells, leading to insulin deficiency and lifelong dependency on exogenous insulin. Higher …

Nephronophthisis (NPH) is an autosomal recessive ciliopathy and a major cause of end-
stage renal disease in children. The main forms, juvenile and adult NPH, are characterized …

The chronic kidney disease-mineral bone disorder (CKD-MBD) is a complex multi-
component syndrome occurring during kidney disease and its progression. Here, we update …

Fibrosis, a pathologic process featured by the excessive deposition of connective tissue
components, can affect virtually every organ and has no satisfactory therapy yet. Fibrotic …