Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Cardiac fibrosis is the excess deposition of extracellular matrix (ECM), such as collagen.
Myofibroblasts are major players in the production of collagen, and are differentiated …

(Myo) fibroblasts are key players for maintaining skin homeostasis and for orchestrating
physiological tissue repair.(Myo) fibroblasts are embedded in a sophisticated extracellular …