The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

The current concepts for development of autoreactive B cells in SLE (systemic lupus
erythematosus) focus on extrinsic stimuli and factors that provoke B cells into tolerance loss …

Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …

Salivarian trypanosomes are extracellular protozoan parasites causing infections in a wide
range of mammalian hosts, with Trypanosoma evansi having the widest geographic …

The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate
immune responses via the TLR-MyD88 (Toll-like receptor-myeloid differentiation primary …

Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic
autoantibodies. Ribonuclease A family member 2 (RNase2) is known to have antiviral …

Abstract CD11c+ T-bet+ B cells generated during ehrlichial infection require CD4+ T cell
help and IL-21 signaling for their development, but the exact T cell subset required had not …

Background Pathological cardiac hypertrophy is regarded as a critical precursor and
independent risk factor of heart failure, and its inhibition prevents the progression of heart …

Hypertension continues to be a major risk factor for global mortality, and recent genome-
wide association studies (GWAS) have expanded in size, leading to the identification of …

Our understanding of immune cells has been mainly due to our ability to identify them by
flow cytometric methods. Improvements in existing flow cytometers, invention of spectral and …