Substantial progress has been made in our understanding of the pathogenetic basis of
myeloproliferative neoplasms. The discovery of mutations in JAK2 over a decade ago …

Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a
heterogeneous group of clonal hematopoietic stem cell disorders characterized by an …

Malignant hematological diseases are mainly because of the occurrence of molecular
abnormalities leading to the deregulation of signaling pathways essential for precise cell …

The germline predisposition associated with the autosomal dominant inheritance of the
14q32 duplication implicating ATG2B/GSKIP genes is characterized by a wide clinical …

Classical Philadelphia-negative myeloproliferative neoplasms (MPNs) are clonal
hematopoietic stem cell-derived disorders characterized by uncontrolled proliferation of …

Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) are clonal
disorders of a hematopoietic stem cell, characterized by an abnormal proliferation of largely …

Myeloproliferative neoplasms (MPNs) are generally acquired as a result of a somatic stem
cell mutation leading to clonal expansion of myeloid precursors. In addition to sporadic …

Myeloproliferative neoplasms (MPN) are clonal hematological malignancies that lead to
overproduction of mature myeloid cells. They are due to acquired mutations in genes …

BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) include three major subgroups—
polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) …

Abstract In 2016, the World Health Organization incorporated 'myeloid neoplasms with
germline predisposition'into its classification of tumors of hematopoietic and lymphoid …