Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Cells in the human body need oxygen to function and survive, and severe deprivation of
oxygen, as occurs in ischaemic heart disease and stroke, is a major cause of mortality …

Because of the central role that red blood cells play in the delivery of oxygen to tissues of the
body, red blood cell mass must be controlled at precise levels. The glycoprotein hormone …

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting
physiological oxygen variations, and its irregularity leads to various human diseases …

Metazoans rely on aerobic energy production, which requires an adequate oxygen supply.
During reduced oxygen supply (hypoxia), the most profound changes in gene expression …

Small molecules inhibiting hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are the
focus of drug development efforts directed toward the treatment of ischemia and metabolic …

Activation of hypoxia-inducible factors (HIF), responsible for tumor angiogenesis and
glycolytic switch, is regulated by reduced oxygen availability. Normally, HIF-α proteins are …

The kidney is the main organ that senses changes in systemic oxygen tension, but it is also
the key detoxification, transit and excretion site of transition metals (TMs). Pivotal to oxygen …

Hydroxylation of two conserved prolyl residues in the N-and C-terminal oxygen-dependent
degradation domains (NODD and CODD) of the α-subunit of hypoxia-inducible factor (HIF) …

Prolyl hydroxylase domain protein 2 (PHD2)‐catalyzed modification of hypoxia‐inducible
factor (HIF)‐α is a key event in oxygen sensing. We previously showed that the zinc finger of …