Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in
inflammation and host defense; however, the underlying molecular mechanism remains …

Liver metastases are associated with poor response to current pharmacological treatments,
including immunotherapy. We describe a lentiviral vector (LV) platform to selectively …

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes and
are ubiquitously used for their anti-inflammatory properties. However, COX inhibition alone …

Tumor‐associated macrophages (TAMs) are one of the most abundant immunosuppressive
cells in the tumor microenvironment and possess crucial functions in facilitating tumor …

Cellular stress in the form of disrupted transcription, loss of organelle integrity, or damage to
nucleic acids can elicit inflammatory responses by activating signaling cascades canonically …

Sepsis-induced cardiomyopathy (SICM) has a poor prognosis, with no effective therapeutic
strategy currently. This study aimed to explore the mechanism underlying SICM and …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …