Redox and antioxidant systems of the malaria parasite Plasmodium falciparum

S Müller - Molecular microbiology, 2004 - Wiley Online Library
The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative
stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the …

Role and Regulation of Glutathione Metabolism in Plasmodium falciparum

S Müller - Molecules, 2015 - mdpi.com
Malaria in humans is caused by one of five species of obligate intracellular protozoan
parasites of the genus Plasmodium. P. falciparum causes the most severe disease and is …

Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

C Huthmacher, A Hoppe, S Bulik, HG Holzhütter - BMC systems biology, 2010 - Springer
Background Despite enormous efforts to combat malaria the disease still afflicts up to half a
billion people each year of which more than one million die. Currently no approved vaccine …

Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico

S Fatumo, K Plaimas, JP Mallm, G Schramm… - Infection, Genetics and …, 2009 - Elsevier
Malaria is one of the world's most common and serious diseases causing death of about 3
million people each year. Its most severe occurrence is caused by the protozoan …

Plasmodium falciparum glutathione S‐transferase—Structural and mechanistic studies on ligand binding and enzyme inhibition

N Hiller, K Fritz‐Wolf, M Deponte, W Wende… - Protein …, 2006 - Wiley Online Library
Glutathione S‐transferase of the malarial parasite Plasmodium falciparum (PfGST)
represents a novel class of GST isoenzymes. Since the architecture of the PfGST substrate …

The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases—Part III: In-silico molecular docking investigations

IV Ogungbe, WN Setzer - Molecules, 2016 - mdpi.com
Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in developing countries. Current treatment options …

WISDOM-II: Screening against multiple targets implicated in malaria using computational grid infrastructures

V Kasam, J Salzemann, M Botha, A Dacosta… - Malaria journal, 2009 - Springer
Background Despite continuous efforts of the international community to reduce the impact
of malaria on developing countries, no significant progress has been made in the recent …

A mu‐class glutathione S‐transferase from the marine shrimp Litopenaeus vannamei: Molecular cloning and active‐site structural modeling

CA Contreras‐Vergara, C Harris‐Valle… - … of Biochemical and …, 2004 - Wiley Online Library
A cDNA clone coding for a mu‐class glutathione S‐transferase (GST) was isolated from a
hepatopancreas cDNA library from the shrimp Litopenaeus vannamei. The deduced amino …

Glutathione S‐transferase from malarial parasites: structural and functional aspects

M Deponte, K Becker - Methods in enzymology, 2005 - Elsevier
Malaria represents an emerging disease because of increasing parasite resistance against
available drugs and because of increasing geographical distribution of the causative agent …

Redox regulation in malaria: current concepts and pharmacotherapeutic implications

M Goyal, A Alam… - Current medicinal …, 2012 - ingentaconnect.com
Malaria imposes a serious threat to human and becomes more prevalent due to the
emergence of drug resistant parasite. Understanding of the underlying mechanism of drug …