The mechanism of secretion and metabolism of gut-derived 5-hydroxytryptamine

N Liu, S Sun, P Wang, Y Sun, Q Hu… - International journal of …, 2021 - mdpi.com
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

GM Mawe, JM Hoffman - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

[HTML][HTML] Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

CS Reigstad, CE Salmonson, JF Rainey III… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Gut microbiota alterations have been described in several diseases with altered
gastrointestinal (GI) motility, and awareness is increasing regarding the role of the gut …

The intestinal microenvironment and functional gastrointestinal disorders

G Barbara, C Feinle-Bisset, UC Ghoshal, J Santos… - Gastroenterology, 2016 - Elsevier
For decades, interactions between the enteric neuromuscular apparatus and the central
nervous system have served as the primary focus of pathophysiological research in the …

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

H Cao, X Liu, Y An, G Zhou, Y Liu, M Xu, W Dong… - Scientific Reports, 2017 - nature.com
Chronic constipation is a prevalent functional gastrointestinal disorder accompanied with
intestinal dysbiosis. However, causal relationship between dysbiosis and constipation …

Mucosal serotonin reuptake transporter expression in irritable bowel syndrome is modulated by gut microbiota via mast cell–prostaglandin E2

J Gao, T Xiong, G Grabauskas, C Owyang - Gastroenterology, 2022 - Elsevier
Background & Aims Increased colonic serotonin (5-HT) level and decreased serotonin
reuptake transporter (SERT) expression in irritable bowel syndrome (IBS) may contribute to …

Molecular mechanisms of Escherichia coli pathogenicity

MA Croxen, BB Finlay - Nature Reviews Microbiology, 2010 - nature.com
Escherichia coli is a remarkable and diverse organism. This normally harmless commensal
needs only to acquire a combination of mobile genetic elements to become a highly adapted …

[HTML][HTML] Human-derived Bifidobacterium dentium modulates the mammalian serotonergic system and gut–brain axis

MA Engevik, B Luck, C Visuthranukul… - Cellular and molecular …, 2021 - Elsevier
Background & Aims The human gut microbiota can regulate production of serotonin (5-
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …

Infectious diarrhea: Cellular and molecular mechanisms

K Hodges, R Gill - Gut microbes, 2010 - Taylor & Francis
Diarrhea caused by enteric infections is a major factor in morbidity and mortality worldwide.
An estimated 2-4 billion episodes of infectious diarrhea occur each year and are especially …

The multifaceted role of serotonin in intestinal homeostasis

N Koopman, D Katsavelis, AS Ten Hove, S Brul… - International journal of …, 2021 - mdpi.com
The monoamine serotonin, 5-hydroxytryptamine (5-HT), is a remarkable molecule with
conserved production in prokaryotes and eukaryotes and a wide range of functions. In the …