The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Many proteins are translocated across the endoplasmic reticulum (ER) membrane in
eukaryotes or the plasma membrane in prokaryotes. These proteins use hydrophobic signal …

The spatial and temporal coordination of protein transport is an essential cornerstone of the
bacterial adaptation to different environmental conditions. By adjusting the protein …

The last∼ 25 years has seen mass spectrometry (MS) emerge as an integral method in the
structural biology toolkit. In particular, MS has enabled the structural characterization of …

Abstract The Sec61/SecY channel allows the translocation of many proteins across the
eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. In …

In bacteria, translocation of most soluble secreted proteins (and outer membrane proteins in
Gram-negative bacteria) across the cytoplasmic membrane by the Sec machinery is …

The insertion and assembly of proteins into the inner membrane of bacteria are crucial for
many cellular processes, including cellular respiration, signal transduction, and ion and pH …

Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

Using a particle-based model, we simulate the behavior of a skyrmion under the influence of
asymmetric funnel geometries and ac driving at zero temperature. We specifically …

SecA belongs to the large class of ATP ases that use the energy of ATP hydrolysis to
perform mechanical work resulting in protein translocation across membranes, protein …