Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease

L Jia, J Piña-Crespo, Y Li - Molecular brain, 2019 - Springer
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …

Wnt signaling deregulation in the aging and Alzheimer's brain

E Palomer, J Buechler, PC Salinas - Frontiers in cellular …, 2019 - frontiersin.org
Growing evidence suggests that synaptic signaling is compromised in the aging brain and in
Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent …

Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease

M Chen, ZY Du, X Zheng, DL Li, RP Zhou… - Neural regeneration …, 2018 - journals.lww.com
This review summarizes and describes the use of curcumin in diagnosis, prevention, and
treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and …

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease

KG Goozee, TM Shah, HR Sohrabi… - British Journal of …, 2016 - cambridge.org
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and
anti-inflammatory properties. Recent studies show that curcumin also possesses …

Transcription factor NRF2 as a promising therapeutic target for Alzheimer's disease

Z Qu, J Sun, W Zhang, J Yu, C Zhuang - Free Radical Biology and …, 2020 - Elsevier
Oxidative stress is considered as one of the pathogenesis of Alzheimer's disease (AD) and
plays an important role in the occurrence and development of AD. Nuclear factor erythroid 2 …

Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression

T Shi, S Shen, Y Shi, Q Wang, G Zhang, J Lin… - Nature …, 2024 - nature.com
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …

The role of the Wnt canonical signaling in neurodegenerative diseases

R Libro, P Bramanti, E Mazzon - Life sciences, 2016 - Elsevier
The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

[HTML][HTML] Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer's disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β …

S Sha, X Shen, Y Cao, L Qu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Currently, Alzheimer's disease (AD) cannot be treated effectively. Mesenchymal stem cells
(MSCs)-derived extracellular vesicles (EVs)(MSC-EVs) exhibit therapeutic effects on many …

Aberrant excitatory–inhibitory synaptic mechanisms in entorhinal cortex microcircuits during the pathogenesis of Alzheimer's disease

AL Petrache, A Rajulawalla, A Shi, A Wetzel… - Cerebral …, 2019 - academic.oup.com
Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …