AIDS patients who develop lymphoma are often treated with transplanted hematopoietic
progenitor cells. As a first step in developing a hematopoietic cell–based gene therapy …

As the HIV pandemic rapidly spread worldwide in the 1980s and 1990s, a new approach to
treat cancer, genetic diseases, and infectious diseases was also emerging. Cell and gene …

The SCID-hu mouse was designed to serve as a preclinical model for the analysis of human
physiology and pathophysiology. In distinction to other immunodeficient mouse models …

A key feature of the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection
is the gradual loss of CD4-positive T cells. A number of gene therapy strategies have been …

We have studied retroviral transgene expression in primary human lymphocytes. Our data
demonstrate that transgene expression is high in activated primary CD4+ T cells but …

Efficient transfer of therapeutic genes into nondividing human cells can be accomplished by
inserting the genes into lentiviruses and infecting the cells with the modified viruses. The …

Retroviral transduction of human hematopoietic stem cells is still limited by lack of
information about conditions that will maximize stem cell self-renewal divisions in vitro. To …

Megakaryocyte-specific expression of the platelet-adhesion receptor, integrin αIIbβ3, is
caused by the presence of regulatory elements of the αIIb promoter that direct high-level …

Lentiviral vectors are promising tools for the development of gene therapy since they can
transduce both quiescent and dividing target cells. Lentiviral vectors may be particularly …

Human umbilical cord blood (UCB) hematopoietic stem cells (HSC) receive increased
attention as a possible target for gene-transfer in gene therapy trials. Diseases affecting the …