Inflammasomes are multi-protein macromolecular complexes that typically comprise of three
units, a sensor, an adaptor and procaspase-1. The assembly of each inflammasome is …

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus (DM).
However, the precise molecular mechanisms remain largely unclear, and it is still a …

Background and aims The pathological roles and mechanisms of Rho-specific guanine
nucleotide dissociation inhibitor 3 (RhoGDI3) in vascular smooth muscle cell (VSMC) …

Chapter 3, the second chapter of the “Infection” part, is divided into two parts: the first part
covers the virulence of bacteria, viruses, fungi, and parasites, while the second part deals …

In Chapter 2, a selected, clinically oriented update of pattern recognition molecules (PRMs)
is presented, as more comprehensively outlined in Vol. 1 of the book Damage-Associated …

Systemic autoinflammatory diseases (SAIDs) delineate a group of diseases that manifest
when the immune system is activated uncontrollably. One cardinal subgroup of SAIDs …

Inflammation is central to the pathogenesis of numerous human diseases. In many contexts,
inflammation drives immune responses which are critical to protection against many …

JI sl/en AI Inflamasom NLRP3 je multiproteinski kompleks, ki ima pomembno vlogo pri
naravni imunosti. Za njegovo delovanje se mora sestaviti in aktivirati. Kanonična aktivacija …

To mimic the effects of complement activation In vivo, systems had to be generated which
would allow complement activation on target cells, from a serum or purified protein source …