Abstract “The Scaffolding Theory of Aging and Cognition (STAC)”, proposed in 2009, is a
conceptual model of cognitive aging that integrated evidence from structural and functional …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Objectives This review focuses on the relationship between obesity and aging and how
these interact to affect cognitive function. The topics covered are guided by the Scaffolding …

Normal aging is associated with cognitive decline and underlying brain dysfunction.
Previous studies concentrated less on brain network changes at a systems level. Our goal …

White matter structure declines with advancing age and has been associated with a decline
in memory and executive processes in older adulthood. Yet, recent research suggests that …

Healthy aging is associated with numerous deficits in cognitive function, which have been
attributed to changes within the prefrontal cortex (PFC). This chapter summarizes some of …

Evidence for the cognitive impact of cancer and cancer treatments has grown over the last
20 years based on studies ranging from prospective assessments with neuropsychological …

We examined functional activation across the adult lifespan in 316 healthy adults aged 20–
89 years on a judgment task that, across conditions, drew upon both semantic knowledge …

Several theories of cognitive compensation have been suggested to explain sustained
cognitive abilities in healthy brain aging and early neurodegenerative processes. The …

The past 25 years have provided a rich discovery of at least four fundamental patterns that
represent structural and functional brain aging across multiple cognitive domains. Of the …