Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …

We report the development of an open-source experimental design via Bayesian
optimization platform for multi-objective reaction optimization. Using high-throughput …

The concurrent installation of C–C and C–N bonds across alkene frameworks represents a
powerful tool to prepare motifs that are ubiquitous in pharmaceuticals and bioactive …

N-heterocycles are crucial due to their biological, chemical, and practical significance. They
are heavily investigated in biological processes involving anticancer, anti-inflammatory …

Conspectus The six-membered heterocycles containing oxygen and nitrogen
(tetrahydropyrans, pyrans, piperidines) are among the most common heterocyclic structures …

Owing to the market competitiveness and urgent societal need, an optimum speed of drug
discovery is an important criterion for successful implementation. Despite the rapid ascent of …

Multidrug‐resistant (MDR) pathogens have created a fatal problem for human health and
antimicrobial treatment. Among the currently available antibiotics, many are inactive against …

Precisely activating chemotherapeutic prodrugs in a tumor-selective manner is an ideal way
to cure cancers without causing systemic toxicities. Although many efforts have been made …