Platelets in the perspective of COVID-19; pathophysiology of thrombocytopenia and its implication as prognostic and therapeutic opportunity
M Delshad, A Safaroghli-Azar… - International …, 2021 - Elsevier
Despite endorsed and exponential research to improve diagnostic and therapeutic
strategies, efforts have not yet converted into a better prospect for patients infected with the …
strategies, efforts have not yet converted into a better prospect for patients infected with the …
[HTML][HTML] Platelet‐inspired nanomedicine in hemostasis thrombosis and thromboinflammation
Platelets are anucleate cell‐fragments derived predominantly from megakaryocytes in the
bone marrow and released in the blood circulation, with a normal count of 150 000–40 000 …
bone marrow and released in the blood circulation, with a normal count of 150 000–40 000 …
Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19
A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular
thrombosis. In fact, COVID-19 autopsy reports have shown widespread thrombotic …
thrombosis. In fact, COVID-19 autopsy reports have shown widespread thrombotic …
Role of SARS-CoV-2-induced cytokines and growth factors in coagulopathy and thromboembolism
Severe COVID-19 patients frequently present thrombotic complications which commonly
lead to multiorgan failure and increase the risk of death. Severe SARS-CoV-2 infection …
lead to multiorgan failure and increase the risk of death. Severe SARS-CoV-2 infection …
Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease …
Platelet-leukocyte crosstalk is commonly manifested by reciprocal links between thrombosis
and inflammation. Platelet thrombus acts as a reactive matrix that recruits leukocytes to the …
and inflammation. Platelet thrombus acts as a reactive matrix that recruits leukocytes to the …
Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation
AL Banka, MV Guevara, ER Brannon… - Nature …, 2023 - nature.com
The combination of inflammation and thrombosis is a hallmark of many cardiovascular
diseases. Under such conditions, platelets are recruited to an area of inflammation by …
diseases. Under such conditions, platelets are recruited to an area of inflammation by …
Coagulation disorders in sepsis and COVID-19—two sides of the same coin? A review of inflammation–coagulation crosstalk in bacterial sepsis and COVID-19
Sepsis is a major cause of morbidity and mortality worldwide. Sepsis-associated coagulation
disorders are involved in the pathogenesis of multiorgan failure and lead to a subsequently …
disorders are involved in the pathogenesis of multiorgan failure and lead to a subsequently …
Platelet–Neutrophil Crosstalk in Thrombosis
LJ Mereweather, A Constantinescu-Bercu… - International journal of …, 2023 - mdpi.com
Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while
neutrophils are the guardians of our immune defences against invading pathogens. The …
neutrophils are the guardians of our immune defences against invading pathogens. The …
Multiphysics and multiscale modeling of microthrombosis in COVID-19
Emerging clinical evidence suggests that thrombosis in the microvasculature of patients with
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Coronavirus disease 2019 (COVID-19) plays an essential role in dictating the disease …
Emerging role of platelet-endothelium interactions in the pathogenesis of severe SARS-CoV-2 infection-associated myocardial injury
TM Rossouw, R Anderson, P Manga… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular dysfunction and disease are common and frequently fatal complications of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Indeed, from …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Indeed, from …