Most mitochondrial proteins are synthesized in the cytosol, translocated into the organelle
and directed along specific sorting pathways. Over the past 20 years,> 30 proteins have …

Loss of proteostasis underlies ageing and neurodegeneration characterized by the
accumulation of protein aggregates and mitochondrial dysfunction,,,,. Although many …

Mutations in the mitochondrial kinase PINK1 and the cytosolic E3 ligase Parkin can cause
Parkinson's disease. Damaged mitochondria accumulate PINK1 on the outer membrane …

The mitochondrial inner membrane consists of two domains, inner boundary membrane and
cristae membrane that are connected by crista junctions. Mitofilin/Fcj1 was reported to be …

The mitochondrial inner membrane contains two non-bilayer‐forming phospholipids,
phosphatidylethanolamine (PE) and cardiolipin (CL). Lack of CL leads to destabilization of …

INTRODUCTION The outer membranes of Gram-negative bacteria, mitochondria, and
chloroplasts characteristically contain β-barrel membrane proteins. These proteins contain …

Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of
functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by …

Mitochondria import a large number of nuclear-encoded proteins via membrane-bound
transport machineries; however, little is known about regulation of the preprotein …

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as
the nucleus, but details about its biology and function in the organelle remain largely …

It is well established that import of proteins into mitochondria can occur after their complete
synthesis by cytosolic ribosomes. Recently, an additional model was revived, proposing that …