Solid tumors require blood vessels for growth, and many new cancer therapies are directed
against the tumor vasculature. The widely held view is that these antiangiogenic therapies …

The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires
recruitment of mural cells, generation of an extracellular matrix and specialization of the …

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination
therapy | Nature Medicine Skip to main content Thank you for visiting nature.com. You are using …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

Using MRI techniques, we show here that normalization of tumor vessels in recurrent
glioblastoma patients by daily administration of AZD2171—an oral tyrosine kinase inhibitor …

The recent landmark Phase III clinical trial with a VEGF-specific antibody suggests that
antiangiogenic therapy must be combined with cytotoxic therapy for the treatment of solid …

Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing
cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown. Here, we …

Studies of the last decades have revealed the importance of angiogenesis for normal growth
and for the pathogenesis of numerous diseases. Much less studied is lymphangiogenesis …

Microcirculation (2010) 17, 206–225. doi: 10.1111/j. 1549‐8719.2010. 00029. x Abstract
Intravital imaging techniques have provided unprecedented insight into tumor …

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that
underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in …