Light chain amyloidosis (AL) is a systemic disease in which abnormally proliferating plasma
cells secrete large amounts of mutated antibody light chains (LCs) that eventually form …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Open searching has proven to be an effective strategy for identifying both known and
unknown modifications in shotgun proteomics experiments. Rather than being limited to a …

Several human proteins cause disease by misfolding and aggregating into amyloid fibril
deposits affecting the surrounding tissues. Multiple other proteins co-associate with the …

The pentraxin serum amyloid P component (SAP) is secreted by the liver and found in
plasma at a concentration of approximately 30 mg/L. SAP is a 25 kDa homopentamer known …

Purpose Ocular adnexal amyloidosis (OAA) may represent localized manifestation of an
underlying systemic process. Accurate identification of the amyloid fibrils can guide the …

The serine protease high-temperature requirement protein A1 (HtrA1) is associated with
protein-misfolding disorders such as Alzheimer's disease and transforming growth factor β …

The application of database search algorithms with very wide precursor mass tolerances for
the “Open Search” paradigm has brought new efforts at post-translational modification …

Omics techniques have been widely applied to veterinary science, although mostly on farm
animal productions and infectious diseases. In canine oncology, on the contrary, the use of …

Background Amyloidosis is a rare and variable disease, characterized by extracellular
deposits of amyloid protein in different tissues and organs. Patients may present with a …