Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase‐1 improves cognitive performance
A Pekcec, N Schülert, B Stierstorfer… - British journal of …, 2018 - Wiley Online Library
Background and Purpose Insufficient prefrontal dopamine 1 (D1) receptor signalling has
been linked to cognitive dysfunction in several psychiatric conditions. Because the PDE1 …
been linked to cognitive dysfunction in several psychiatric conditions. Because the PDE1 …
Histamine H3 receptor activation prevents dopamine D1 receptor-mediated inhibition of dopamine release in the rat striatum: a microdialysis study
A Alfaro-Rodriguez, M Alonso-Spilsbury… - Neuroscience …, 2013 - Elsevier
Abstract Histamine H 3 receptors (H 3 Rs) co-localize with dopamine (DA) D 1 receptors (D
1 Rs) on striatal medium spiny neurons and functionally antagonize D 1 R-mediated …
1 Rs) on striatal medium spiny neurons and functionally antagonize D 1 R-mediated …
Dopamine D1 receptor activation maintains motor coordination and balance in rats
A Avila-Luna, A Gálvez-Rosas, A Durand-Rivera… - Metabolic Brain …, 2018 - Springer
Dopamine (DA) modulates motor coordination, and its depletion, as in Parkinson's disease,
produces motor impairment. The basal ganglia, cerebellum and cerebral cortex are …
produces motor impairment. The basal ganglia, cerebellum and cerebral cortex are …
Dopamine D1 receptor activation maintains motor coordination in injured rats but does not accelerate the recovery of the motor coordination deficit
A Avila-Luna, A Gálvez-Rosas… - Behavioural Brain …, 2018 - Elsevier
The sensorimotor cortex and the striatum are interconnected by the corticostriatal pathway,
suggesting that cortical injury alters the striatal function that is associated with skilled …
suggesting that cortical injury alters the striatal function that is associated with skilled …
Influence of DRD1 and DRD3 Polymorphisms in the Occurrence of Motor Effects in Patients with Sporadic Parkinson's Disease
EUD Dos Santos, EBC Duarte, LMR Miranda… - NeuroMolecular …, 2019 - Springer
Parkinson's disease (PD) is a multisystem disorder that affects 2–3% of the population≥ 65
years of age. The main pharmacologic agent use in the treatment of clinical symptoms of PD …
years of age. The main pharmacologic agent use in the treatment of clinical symptoms of PD …
Los ganglios basales: la participación dopaminérgica estriatal
A Avila-Luna, A Bueno-Nava - Investigación en Discapacidad, 2014 - medigraphic.com
Los ganglios basales (GB) están asociados a las funciones motoras y no motoras. El
neoestriado forma parte de los GB y su función es críticamente modulada por la dopamina a …
neoestriado forma parte de los GB y su función es críticamente modulada por la dopamina a …
[HTML][HTML] Neurodevelopmental and cognitive behavior of glutaryl-CoA dehydrogenase deficient knockout mice
ENB Busanello, L Pettenuzzo, PH Botton, P Pandolfo… - Life Sciences, 2013 - Elsevier
AIMS: The establishment of a genetic knockout murine model of glutaric acidemia type I
(GAI) with complete loss of glutaryl-CoA dehydrogenase (GCDH) activity has been used to …
(GAI) with complete loss of glutaryl-CoA dehydrogenase (GCDH) activity has been used to …
Effects of the neurotoxin MPTP and pargyline protection on extracellular energy metabolites and dopamine levels in the striatum of freely moving rats
G Bazzu, G Rocchitta, R Migheli, MD Alvau, M Zinellu… - Brain research, 2013 - Elsevier
The neurotoxin MPTP is known to induce dopamine release and depletion of ATP in the
striatum of rats. Therefore, we studied the changes induced by MPTP and pargyline …
striatum of rats. Therefore, we studied the changes induced by MPTP and pargyline …
D1 Antagonists and D2 Agonists Have Opposite Effects on the Metabolism of Dopamine in the Rat Striatum
A Avila-Luna, J Prieto-Leyva, A Gálvez-Rosas… - Neurochemical …, 2015 - Springer
The striatum is known to possess high levels of D 1-like and D 2-like receptors (D 1 Rs and
D 2 Rs, respectively). We have previously shown that selective inhibition of D 1 Rs increases …
D 2 Rs, respectively). We have previously shown that selective inhibition of D 1 Rs increases …
Neuroprotection by freshwater clam extract against the neurotoxin MPTP in C57BL/6 mice
CC Hsieh, MS Lin, KF Hua, WJ Chen, CC Lin - Neuroscience Letters, 2017 - Elsevier
Freshwater clams are a popular health food in Asia and are traditionally used to prevent
hepatic inflammation. Freshwater clam extract (FCE) inhibits inflammatory responses in …
hepatic inflammation. Freshwater clam extract (FCE) inhibits inflammatory responses in …