Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection

A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …

First contact: the role of respiratory cilia in host-pathogen interactions in the airways

LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …

Evidence of severe acute respiratory syndrome coronavirus 2 replication and tropism in the lungs, airways, and vascular endothelium of patients with fatal coronavirus …

J Bhatnagar, J Gary, S Reagan-Steiner… - The Journal of …, 2021 - academic.oup.com
Background The coronavirus disease 2019 (COVID-19) pandemic continues to produce
substantial morbidity and mortality. To understand the reasons for the wide-spectrum …

COVIDOA: a novel evolutionary optimization algorithm based on coronavirus disease replication lifecycle

AM Khalid, KM Hosny, S Mirjalili - Neural Computing and Applications, 2022 - Springer
This paper presents a novel bio-inspired optimization algorithm called Coronavirus
Optimization Algorithm (COVIDOA). COVIDOA is an evolutionary search strategy that mimics …

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

[HTML][HTML] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

D Bartolini, AM Stabile, S Bastianelli, D Giustarini… - Redox biology, 2021 - Elsevier
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the
host cell. In this context, specific alterations of the levels and homeostatic function of the …

HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV

A Milewska, Y Chi, A Szczepanski… - Journal of …, 2021 - Am Soc Microbiol
Among seven coronaviruses that infect humans, three (severe acute respiratory syndrome
coronavirus [SARS-CoV], Middle East respiratory syndrome coronavirus [MERS-CoV], and …

In vitro and in vivo models for studying SARS-CoV-2, the etiological agent responsible for COVID-19 pandemic

RB Rosa, WM Dantas, JCF do Nascimento… - Viruses, 2021 - mdpi.com
The emergence and rapid worldwide spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …

[HTML][HTML] SARS-CoV-2 infection of airway epithelial cells

G Ryu, HW Shin - Immune network, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has been spreading worldwide since its outbreak in December 2019, and …